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CSF CKBB was usually sampled 48 to 72 hours after cardiac arrest and was strongly associated with awakening(p<<0.001).The median was 4 U/l for 61 patients who awakened and 191 U/l for 290 who never awakened.For those who awakened,75%of CKBB levels were<25 U/l,and for those who never awakened, 75%were>86 U/l.The highest value in a patient who awakened was 204 u?1,a cutoff that yielded a specificity of 100%of never awakening but a sensitivity of fourty-eight percent.Only nine patients who awakened had CSF CKBB values greater than 50 U/l,and none regained independence in activities of daily living.Only three unconscious patients were still alive at last contact,with follow-up of 63,107 and 109 months.using logistic regression,the probability of never awakening given a CSF CKBB result can be estimated as:1/(1+L),where L=e raised to(0.1267-0.0211 x CSF CKBB[U/l]).CSF CKBB measurement helps to estimate degree of brain damage and thus neurologic prognosis after cardiac arrest.However,results of this retrospective study could reflect in part a self-fulfilling prophecy. |
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